Leukotriene-Receptor Antagonists Versus Placebo in the Treatment of Asthma in Adults and Adolescents

Role of leukotriene receptor antagonists in asthma.

Asthma is a chronic inflammatory disease that affects >300 million people worldwide. However, inhaled corticosteroids (ICS), the gold standard therapy for persistent asthma, cannot suppress every component of airway inflammation and often fail to adequately penetrate the small airways in order completely suppress eosinophilia. Cysteinyl leukotrienes are important inflammatory factors that are i...

Leukotriene receptor antagonists for the treatment of asthma.

Leukotriene receptor antagonists (LTRAs) are novel medications that provide symptom control in patients with persistent asthma. Current guidelines recommend the use of LTRAs as a treatment option for patients with mild-persistent asthma of at least 12 years of age. As illustrated by the results of controlled, multicenter clinical trials with zafirlukast and montelukast, as well as studies with ...

Leukotriene receptor antagonists: useful in acute asthma?

Inhaled glucocorticoids versus leukotriene receptor antagonists as single agent asthma treatment: systematic review of current evidence.

OBJECTIVE To compare the safety and efficacy of anti-leukotrienes and inhaled glucocorticoids as monotherapy in people with asthma. DESIGN Systematic review of randomised controlled trials comparing anti-leukotrienes with inhaled glucocorticoids for 28 days or more in children and adults. MAIN OUTCOME MEASURE Rate of exacerbations that required treatment with systemic glucocorticoids. RES...

Beneficial antiinflammatory effects of leukotriene receptor antagonists in asthma.

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